Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2481851..2482479 Replicon chromosome
Accession NZ_CP102682
Organism Leptospira borgpetersenii serovar Javanica strain 4-I

Toxin (Protein)


Gene name vapC Uniprot ID M6E4U3
Locus tag LIX27_RS10640 Protein ID WP_002724218.1
Coordinates 2482078..2482479 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LIX27_RS10635 Protein ID WP_010705987.1
Coordinates 2481851..2482081 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX27_RS10620 (LIX27_10620) 2479824..2480204 - 381 WP_258203851.1 hypothetical protein -
LIX27_RS10625 (LIX27_10625) 2480706..2480934 - 229 Protein_2095 hypothetical protein -
LIX27_RS10630 (LIX27_10630) 2481448..2481585 - 138 WP_002736206.1 hypothetical protein -
LIX27_RS10635 (LIX27_10635) 2481851..2482081 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LIX27_RS10640 (LIX27_10640) 2482078..2482479 + 402 WP_002724218.1 type II toxin-antitoxin system VapC family toxin Toxin
LIX27_RS10645 (LIX27_10645) 2482625..2482804 - 180 WP_002724268.1 hypothetical protein -
LIX27_RS10650 (LIX27_10650) 2482914..2484596 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
LIX27_RS10655 (LIX27_10655) 2485005..2485550 + 546 WP_170874669.1 metal-dependent hydrolase -
LIX27_RS10660 (LIX27_10660) 2486343..2486633 + 291 WP_002736220.1 YciI family protein -
LIX27_RS10665 (LIX27_10665) 2486642..2487338 - 697 Protein_2103 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15501.23 Da        Isoelectric Point: 9.9288

>T253999 WP_002724218.1 NZ_CP102682:2482078-2482479 [Leptospira borgpetersenii serovar Javanica]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHFERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT253999 WP_010705987.1 NZ_CP102682:2481851-2482081 [Leptospira borgpetersenii serovar Javanica]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M6E4U3

Antitoxin

Source ID Structure

References