Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2481866..2482494 Replicon chromosome
Accession NZ_CP102680
Organism Leptospira borgpetersenii serovar Javanica strain I2

Toxin (Protein)


Gene name vapC Uniprot ID M6E4U3
Locus tag NU962_RS10600 Protein ID WP_002724218.1
Coordinates 2482093..2482494 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NU962_RS10595 Protein ID WP_010705987.1
Coordinates 2481866..2482096 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU962_RS10580 (NU962_10580) 2479839..2480537 - 699 WP_002724172.1 hypothetical protein -
NU962_RS10585 (NU962_10585) 2480720..2480948 - 229 Protein_2087 hypothetical protein -
NU962_RS10590 (NU962_10590) 2481463..2481600 - 138 WP_002736206.1 hypothetical protein -
NU962_RS10595 (NU962_10595) 2481866..2482096 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NU962_RS10600 (NU962_10600) 2482093..2482494 + 402 WP_002724218.1 type II toxin-antitoxin system VapC family toxin Toxin
NU962_RS10605 (NU962_10605) 2482640..2482819 - 180 WP_002724268.1 hypothetical protein -
NU962_RS10610 (NU962_10610) 2482929..2484611 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
NU962_RS10615 (NU962_10615) 2485020..2485565 + 546 WP_170874669.1 metal-dependent hydrolase -
NU962_RS10620 (NU962_10620) 2486358..2486648 + 291 WP_002736220.1 YciI family protein -
NU962_RS10625 (NU962_10625) 2486657..2487353 - 697 Protein_2095 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15501.23 Da        Isoelectric Point: 9.9288

>T253996 WP_002724218.1 NZ_CP102680:2482093-2482494 [Leptospira borgpetersenii serovar Javanica]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHFERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT253996 WP_010705987.1 NZ_CP102680:2481866-2482096 [Leptospira borgpetersenii serovar Javanica]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M6E4U3

Antitoxin

Source ID Structure

References