Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 480648..481213 Replicon chromosome
Accession NZ_CP102680
Organism Leptospira borgpetersenii serovar Javanica strain I2

Toxin (Protein)


Gene name mazF Uniprot ID V6I350
Locus tag NU962_RS02105 Protein ID WP_002753850.1
Coordinates 480648..480896 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NU962_RS02110 Protein ID WP_011670965.1
Coordinates 480890..481213 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU962_RS02085 (NU962_02085) 475697..476698 + 1002 WP_002732926.1 metallophosphoesterase -
NU962_RS02090 (NU962_02090) 476701..477378 + 678 WP_002725755.1 hypothetical protein -
NU962_RS02095 (NU962_02095) 477375..477791 + 417 WP_002725741.1 hypothetical protein -
NU962_RS02100 (NU962_02100) 477772..479952 + 2181 WP_002759426.1 ATP-dependent DNA helicase RecG -
NU962_RS02105 (NU962_02105) 480648..480896 + 249 WP_002753850.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
NU962_RS02110 (NU962_02110) 480890..481213 + 324 WP_011670965.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
NU962_RS02115 (NU962_02115) 481649..483184 + 1536 WP_258203911.1 phosphomethylpyrimidine synthase ThiC -
NU962_RS02120 (NU962_02120) 483563..484216 + 654 Protein_413 helicase-related protein -
NU962_RS02125 (NU962_02125) 484591..484935 - 345 WP_002728323.1 TIGR04452 family lipoprotein -
NU962_RS02130 (NU962_02130) 485269..486012 + 744 WP_002728313.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(6-49)

Antitoxin

mRNA interferase PemK-like

(5-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9459.00 Da        Isoelectric Point: 5.1749

>T253994 WP_002753850.1 NZ_CP102680:480648-480896 [Leptospira borgpetersenii serovar Javanica]
MKALVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKSMSSNKDDKLLIPDSIDLSDKDW
EW

Download         Length: 249 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12296.80 Da        Isoelectric Point: 10.5161

>AT253994 WP_011670965.1 NZ_CP102680:480890-481213 [Leptospira borgpetersenii serovar Javanica]
MVISQYEVYLINLDPTVGHEIKKSRPCVIISPNEMNKTIGTIIITPMTTKSRSYPTRVELTFQGKKGWIVLDQIRTVDKI
RLIKKLGKIDPKTVNKMKLIIKEMLVD

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6I350

Antitoxin

Source ID Structure

References