Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4899840..4900471 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag NU949_RS25990 Protein ID WP_001259388.1
Coordinates 4899840..4900115 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NU949_RS25995 Protein ID WP_000593555.1
Coordinates 4900112..4900471 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS25975 (4894844) 4894844..4895911 + 1068 WP_000361485.1 HlyD family secretion protein -
NU949_RS25980 (4895908) 4895908..4898643 + 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
NU949_RS25985 (4898643) 4898643..4899767 + 1125 WP_001314210.1 ABC transporter permease -
NU949_RS25990 (4899840) 4899840..4900115 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
NU949_RS25995 (4900112) 4900112..4900471 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NU949_RS26000 (4900591) 4900591..4900992 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NU949_RS26005 (4900998) 4900998..4901804 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NU949_RS26010 (4901801) 4901801..4902565 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NU949_RS26015 (4902565) 4902565..4903398 - 834 WP_038999760.1 nickel ABC transporter permease subunit NikC -
NU949_RS26020 (4903395) 4903395..4904339 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T253993 WP_001259388.1 NZ_CP102679:4899840-4900115 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT253993 WP_000593555.1 NZ_CP102679:4900112-4900471 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References