Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4118252..4118749 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NU949_RS22320 Protein ID WP_001173343.1
Coordinates 4118252..4118425 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NU949_RS22325 Protein ID WP_000398619.1
Coordinates 4118453..4118749 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS22310 (4114922) 4114922..4116379 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NU949_RS22315 (4116616) 4116616..4118133 + 1518 WP_001295074.1 lysine--tRNA ligase -
NU949_RS22320 (4118252) 4118252..4118425 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NU949_RS22325 (4118453) 4118453..4118749 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NU949_RS22330 (4118976) 4118976..4119248 - 273 WP_000405649.1 GNAT family N-acetyltransferase -
NU949_RS22335 (4119260) 4119260..4119490 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NU949_RS22340 (4119671) 4119671..4121302 + 1632 WP_001216487.1 sensor histidine kinase -
NU949_RS22345 (4121299) 4121299..4122018 + 720 WP_125090678.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T253991 WP_001173343.1 NZ_CP102679:c4118425-4118252 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT253991 WP_000398619.1 NZ_CP102679:c4118749-4118453 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References