Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4021787..4022382 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NU949_RS21815 Protein ID WP_000239579.1
Coordinates 4021787..4022137 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NU949_RS21820 Protein ID WP_001223208.1
Coordinates 4022131..4022382 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS21795 (4017063) 4017063..4018085 - 1023 WP_001296689.1 ABC transporter permease -
NU949_RS21800 (4018099) 4018099..4019601 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
NU949_RS21805 (4019911) 4019911..4020867 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NU949_RS21810 (4021177) 4021177..4021707 + 531 WP_000055072.1 inorganic diphosphatase -
NU949_RS21815 (4021787) 4021787..4022137 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NU949_RS21820 (4022131) 4022131..4022382 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NU949_RS21825 (4022595) 4022595..4022936 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NU949_RS21830 (4022939) 4022939..4026718 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T253990 WP_000239579.1 NZ_CP102679:c4022137-4021787 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT253990 WP_001223208.1 NZ_CP102679:c4022382-4022131 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References