253986

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3237370..3238207 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag NU949_RS17945 Protein ID WP_000227784.1
Coordinates 3237665..3238207 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag NU949_RS17940 Protein ID WP_001297137.1
Coordinates 3237370..3237681 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS17915 (3232390) 3232390..3233337 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
NU949_RS17920 (3233359) 3233359..3235350 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
NU949_RS17925 (3235340) 3235340..3235954 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
NU949_RS17930 (3235954) 3235954..3236283 + 330 WP_072649523.1 cytochrome o ubiquinol oxidase subunit IV -
NU949_RS17935 (3236295) 3236295..3237185 + 891 WP_000971336.1 heme o synthase -
NU949_RS17940 (3237370) 3237370..3237681 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
NU949_RS17945 (3237665) 3237665..3238207 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
NU949_RS17950 (3238263) 3238263..3239198 - 936 WP_001365761.1 tetratricopeptide repeat protein -
NU949_RS17955 (3239606) 3239606..3240970 + 1365 WP_001000974.1 MFS transporter -
NU949_RS17960 (3241098) 3241098..3241589 - 492 WP_001138904.1 nucleotide binding protein YajQ -
NU949_RS17965 (3241757) 3241757..3242668 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T253986 WP_000227784.1 NZ_CP102679:3237665-3238207 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT253986 WP_001297137.1 NZ_CP102679:3237370-3237681 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References