Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3203294..3203912 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NU949_RS17775 Protein ID WP_001291435.1
Coordinates 3203694..3203912 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NU949_RS17770 Protein ID WP_000344800.1
Coordinates 3203294..3203668 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS17760 (3198383) 3198383..3199576 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NU949_RS17765 (3199599) 3199599..3202748 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NU949_RS17770 (3203294) 3203294..3203668 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NU949_RS17775 (3203694) 3203694..3203912 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NU949_RS17780 (3204083) 3204083..3204634 + 552 WP_000102564.1 maltose O-acetyltransferase -
NU949_RS17785 (3204750) 3204750..3205220 + 471 WP_000136192.1 YlaC family protein -
NU949_RS17790 (3205384) 3205384..3206934 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NU949_RS17795 (3206976) 3206976..3207329 - 354 WP_000878141.1 DUF1428 family protein -
NU949_RS17805 (3207708) 3207708..3208019 + 312 WP_000409911.1 MGMT family protein -
NU949_RS17810 (3208050) 3208050..3208622 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253985 WP_001291435.1 NZ_CP102679:3203694-3203912 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT253985 WP_000344800.1 NZ_CP102679:3203294-3203668 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References