Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2214735..2215373 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NU949_RS12990 Protein ID WP_000813794.1
Coordinates 2215197..2215373 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NU949_RS12985 Protein ID WP_001270286.1
Coordinates 2214735..2215151 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS12965 (2209887) 2209887..2210828 - 942 WP_072649490.1 ABC transporter permease -
NU949_RS12970 (2210829) 2210829..2211842 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NU949_RS12975 (2211860) 2211860..2213005 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
NU949_RS12980 (2213250) 2213250..2214656 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
NU949_RS12985 (2214735) 2214735..2215151 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NU949_RS12990 (2215197) 2215197..2215373 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NU949_RS12995 (2215595) 2215595..2215825 + 231 WP_000494244.1 YncJ family protein -
NU949_RS13000 (2215917) 2215917..2217878 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NU949_RS13005 (2217951) 2217951..2218487 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NU949_RS13010 (2218579) 2218579..2219754 + 1176 WP_001236215.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T253984 WP_000813794.1 NZ_CP102679:c2215373-2215197 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT253984 WP_001270286.1 NZ_CP102679:c2215151-2214735 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References