Detailed information of TA system TA025398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 5350395..5350866
• Replicon: chromosome
• Accession: NC_015675
• Organism: Mesorhizobium opportunistum WSM2075

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F7Y636
• Locus tag: MESOP_RS25910
• Protein ID: WP_013896301.1
• Coordinates: 5350395..5350661 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: MESOP_RS25915
• Protein ID: WP_013896302.1
• Coordinates: 5350645..5350866 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MESOP_RS25885	5345486..5346376	-	891	WP_013896297.1	YicC family protein	-
MESOP_RS25890	5346525..5347778	-	1254	WP_013896298.1	endolytic transglycosylase MltG	-
MESOP_RS25895	5347881..5349143	-	1263	WP_013896299.1	beta-ketoacyl-ACP synthase II	-
MESOP_RS25900	5349178..5349414	-	237	WP_006203723.1	acyl carrier protein	-
MESOP_RS25905	5349626..5350363	-	738	WP_013896300.1	3-oxoacyl-[acyl-carrier-protein] reductase	-
MESOP_RS25910	5350395..5350661	-	267	WP_013896301.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MESOP_RS25915	5350645..5350866	-	222	WP_013896302.1	ribbon-helix-helix protein, CopG family	Antitoxin
MESOP_RS25920	5350922..5351860	-	939	WP_013896303.1	ACP S-malonyltransferase	-
MESOP_RS25925	5352105..5354066	+	1962	WP_174324785.1	LTA synthase family protein	-
MESOP_RS25930	5354554..5355045	+	492	WP_013896305.1	30S ribosomal protein S6	-
MESOP_RS25935	5355045..5355293	+	249	WP_006203718.1	30S ribosomal protein S18	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-39)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10340.99 Da
• Isoelectric Point: 10.5737

>T25398 WP_013896301.1 NC_015675:c5350661-5350395 [Mesorhizobium opportunistum WSM2075]
VAWTLEYARSARKFVEKLDPKTRHRIRDFIENRIAVLDNPREAGKALKGPLATFWRYRVGDYRIICDVQDSRLVVLVVTI
GHRGDIYR

Nucleotide

• Length: 267 bp

>T25398 NC_015675:c5350661-5350395 [Mesorhizobium opportunistum WSM2075]
GTGGCCTGGACGCTTGAATACGCCCGTTCAGCGCGCAAATTCGTTGAAAAGCTGGATCCAAAAACGCGGCATCGCATCCG
GGACTTCATTGAAAACCGTATCGCGGTGCTCGACAATCCACGTGAAGCCGGCAAGGCGCTGAAGGGCCCTTTGGCGACTT
TTTGGAGATACCGGGTTGGGGATTATCGCATTATCTGCGATGTGCAGGACAGCCGGCTGGTCGTTCTGGTGGTAACCATC
GGCCACCGTGGTGACATCTACAGATAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8639.78 Da
• Isoelectric Point: 4.3648

>AT25398 WP_013896302.1 NC_015675:c5350866-5350645 [Mesorhizobium opportunistum WSM2075]
MPTSIRLAPEIEERLDFLAARTGRSKAYYLRELIERGIEEMEDYYLAAEVLERIRRGEEDVMKGEDFWRGLDA

Nucleotide

• Length: 222 bp

>AT25398 NC_015675:c5350866-5350645 [Mesorhizobium opportunistum WSM2075]
ATGCCGACCTCTATAAGACTGGCTCCCGAGATCGAGGAGCGCCTGGATTTCCTGGCGGCCAGGACCGGCCGCAGCAAGGC
TTACTATCTGCGCGAACTCATCGAGCGCGGTATCGAGGAAATGGAAGACTATTACCTCGCCGCTGAAGTTCTGGAGCGGA
TCAGGCGTGGCGAAGAGGATGTCATGAAGGGCGAGGACTTCTGGCGTGGCCTGGACGCTTGA

Structures

Toxin

• AlphaFold DB: F7Y636