Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1063112..1063737 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NU949_RS07345 Protein ID WP_000911330.1
Coordinates 1063339..1063737 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NU949_RS07340 Protein ID WP_000450524.1
Coordinates 1063112..1063339 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS07315 (1058915) 1058915..1059385 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NU949_RS07320 (1059385) 1059385..1059957 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NU949_RS07325 (1060103) 1060103..1060981 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NU949_RS07330 (1060998) 1060998..1062032 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
NU949_RS07335 (1062245) 1062245..1062958 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NU949_RS07340 (1063112) 1063112..1063339 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NU949_RS07345 (1063339) 1063339..1063737 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NU949_RS07350 (1063884) 1063884..1064747 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NU949_RS07355 (1064762) 1064762..1066777 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
NU949_RS07360 (1066851) 1066851..1067549 + 699 WP_000679812.1 esterase -
NU949_RS07365 (1067630) 1067630..1067830 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T253976 WP_000911330.1 NZ_CP102679:1063339-1063737 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT253976 WP_000450524.1 NZ_CP102679:1063112-1063339 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References