Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 639565..640219 Replicon chromosome
Accession NZ_CP102679
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag NU949_RS05330 Protein ID WP_000244772.1
Coordinates 639812..640219 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NU949_RS05325 Protein ID WP_000354046.1
Coordinates 639565..639831 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS05300 (634853) 634853..635596 + 744 WP_000951964.1 SDR family oxidoreductase -
NU949_RS05305 (635653) 635653..637086 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
NU949_RS05310 (637131) 637131..637442 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
NU949_RS05315 (637606) 637606..638265 + 660 WP_000250274.1 hemolysin III family protein -
NU949_RS05320 (638342) 638342..639322 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NU949_RS05325 (639565) 639565..639831 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NU949_RS05330 (639812) 639812..640219 + 408 WP_000244772.1 protein YgfX Toxin
NU949_RS05335 (640259) 640259..640780 - 522 WP_001055874.1 flavodoxin FldB -
NU949_RS05340 (640892) 640892..641788 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NU949_RS05345 (641813) 641813..642523 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NU949_RS05350 (642529) 642529..644262 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T253974 WP_000244772.1 NZ_CP102679:639812-640219 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT253974 WP_000354046.1 NZ_CP102679:639565-639831 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References