Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 131439..132064 Replicon plasmid pXH989-CTX
Accession NZ_CP102676
Organism Escherichia coli strain XH989

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NU949_RS00785 Protein ID WP_000911313.1
Coordinates 131666..132064 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag NU949_RS00780 Protein ID WP_000450520.1
Coordinates 131439..131666 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU949_RS00780 (131439) 131439..131666 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
NU949_RS00785 (131666) 131666..132064 + 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
NU949_RS00790 (132073) 132073..134226 - 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
NU949_RS00795 (134479) 134479..135210 - 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
NU949_RS00800 (135242) 135242..135739 - 498 WP_000605857.1 entry exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / rmtB / aac(3)-IId / aadA5 / qacE / sul1 / mph(A) / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / fosA3 / blaCTX-M-65 / sitABCD iroN / iroE / iroD / iroC / iroB / iutA / iucD / iucC / iucB / iucA 1..188009 188009


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T253965 WP_000911313.1 NZ_CP102676:131666-132064 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT253965 WP_000450520.1 NZ_CP102676:131439-131666 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References