Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4158272..4158897 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NU950_RS22250 Protein ID WP_000911330.1
Coordinates 4158499..4158897 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NU950_RS22245 Protein ID WP_000450524.1
Coordinates 4158272..4158499 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS22220 (4154075) 4154075..4154545 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NU950_RS22225 (4154545) 4154545..4155117 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NU950_RS22230 (4155263) 4155263..4156141 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NU950_RS22235 (4156158) 4156158..4157192 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
NU950_RS22240 (4157405) 4157405..4158118 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NU950_RS22245 (4158272) 4158272..4158499 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NU950_RS22250 (4158499) 4158499..4158897 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NU950_RS22255 (4159044) 4159044..4159907 + 864 WP_001267498.1 neutral zinc metallopeptidase -
NU950_RS22260 (4159922) 4159922..4161937 + 2016 WP_000829292.1 tRNA cytosine(34) acetyltransferase TmcA -
NU950_RS22265 (4162011) 4162011..4162709 + 699 WP_000679812.1 esterase -
NU950_RS22270 (4162790) 4162790..4162990 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T253954 WP_000911330.1 NZ_CP102675:4158499-4158897 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT253954 WP_000450524.1 NZ_CP102675:4158272-4158499 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References