Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3734720..3735374 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag NU950_RS20235 Protein ID WP_000244772.1
Coordinates 3734967..3735374 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NU950_RS20230 Protein ID WP_000354046.1
Coordinates 3734720..3734986 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS20205 (3730008) 3730008..3730751 + 744 WP_000951964.1 SDR family oxidoreductase -
NU950_RS20210 (3730808) 3730808..3732241 - 1434 WP_001344773.1 6-phospho-beta-glucosidase BglA -
NU950_RS20215 (3732286) 3732286..3732597 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
NU950_RS20220 (3732761) 3732761..3733420 + 660 WP_000250274.1 hemolysin III family protein -
NU950_RS20225 (3733497) 3733497..3734477 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NU950_RS20230 (3734720) 3734720..3734986 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NU950_RS20235 (3734967) 3734967..3735374 + 408 WP_000244772.1 protein YgfX Toxin
NU950_RS20240 (3735414) 3735414..3735935 - 522 WP_001055874.1 flavodoxin FldB -
NU950_RS20245 (3736047) 3736047..3736943 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NU950_RS20250 (3736968) 3736968..3737678 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NU950_RS20255 (3737684) 3737684..3739417 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T253952 WP_000244772.1 NZ_CP102675:3734967-3735374 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT253952 WP_000354046.1 NZ_CP102675:3734720-3734986 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References