Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3064429..3065060 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name hicA Uniprot ID F4NNK6
Locus tag NU950_RS16790 Protein ID WP_001259388.1
Coordinates 3064429..3064704 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NU950_RS16795 Protein ID WP_000593555.1
Coordinates 3064701..3065060 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS16775 (3059433) 3059433..3060500 + 1068 WP_000361485.1 HlyD family secretion protein -
NU950_RS16780 (3060497) 3060497..3063232 + 2736 WP_000149125.1 ribosome-associated ATPase/putative transporter RbbA -
NU950_RS16785 (3063232) 3063232..3064356 + 1125 WP_001314210.1 ABC transporter permease -
NU950_RS16790 (3064429) 3064429..3064704 + 276 WP_001259388.1 type II toxin-antitoxin system HicA family toxin Toxin
NU950_RS16795 (3064701) 3064701..3065060 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NU950_RS16800 (3065180) 3065180..3065581 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NU950_RS16805 (3065587) 3065587..3066393 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NU950_RS16810 (3066390) 3066390..3067154 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NU950_RS16815 (3067154) 3067154..3067987 - 834 WP_038999760.1 nickel ABC transporter permease subunit NikC -
NU950_RS16820 (3067984) 3067984..3068928 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10151.89 Da        Isoelectric Point: 10.7076

>T253948 WP_001259388.1 NZ_CP102675:3064429-3064704 [Escherichia coli]
MRTKVQALRKKQKNTLDQIVKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT253948 WP_000593555.1 NZ_CP102675:3064701-3065060 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A0FFA2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References