Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 2282849..2283346 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NU950_RS13120 Protein ID WP_001173343.1
Coordinates 2282849..2283022 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NU950_RS13125 Protein ID WP_000398619.1
Coordinates 2283050..2283346 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS13110 (2279519) 2279519..2280976 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
NU950_RS13115 (2281213) 2281213..2282730 + 1518 WP_001295074.1 lysine--tRNA ligase -
NU950_RS13120 (2282849) 2282849..2283022 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NU950_RS13125 (2283050) 2283050..2283346 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NU950_RS13130 (2283573) 2283573..2283845 - 273 WP_000405649.1 GNAT family N-acetyltransferase -
NU950_RS13135 (2283857) 2283857..2284087 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NU950_RS13140 (2284268) 2284268..2285899 + 1632 WP_001216487.1 sensor histidine kinase -
NU950_RS13145 (2285896) 2285896..2286615 + 720 WP_125090678.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T253946 WP_001173343.1 NZ_CP102675:c2283022-2282849 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT253946 WP_000398619.1 NZ_CP102675:c2283346-2283050 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References