253941

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1401969..1402806 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag NU950_RS08745 Protein ID WP_000227784.1
Coordinates 1402264..1402806 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag NU950_RS08740 Protein ID WP_001297137.1
Coordinates 1401969..1402280 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS08715 (1396989) 1396989..1397936 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
NU950_RS08720 (1397958) 1397958..1399949 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
NU950_RS08725 (1399939) 1399939..1400553 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
NU950_RS08730 (1400553) 1400553..1400882 + 330 WP_072649523.1 cytochrome o ubiquinol oxidase subunit IV -
NU950_RS08735 (1400894) 1400894..1401784 + 891 WP_000971336.1 heme o synthase -
NU950_RS08740 (1401969) 1401969..1402280 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
NU950_RS08745 (1402264) 1402264..1402806 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
NU950_RS08750 (1402862) 1402862..1403797 - 936 WP_001365761.1 tetratricopeptide repeat protein -
NU950_RS08755 (1404205) 1404205..1405569 + 1365 WP_001000974.1 MFS transporter -
NU950_RS08760 (1405697) 1405697..1406188 - 492 WP_001138904.1 nucleotide binding protein YajQ -
NU950_RS08765 (1406356) 1406356..1407267 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T253941 WP_000227784.1 NZ_CP102675:1402264-1402806 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT253941 WP_001297137.1 NZ_CP102675:1401969-1402280 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References