Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1367893..1368511 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NU950_RS08575 Protein ID WP_001291435.1
Coordinates 1368293..1368511 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NU950_RS08570 Protein ID WP_000344800.1
Coordinates 1367893..1368267 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS08560 (1362982) 1362982..1364175 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NU950_RS08565 (1364198) 1364198..1367347 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NU950_RS08570 (1367893) 1367893..1368267 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NU950_RS08575 (1368293) 1368293..1368511 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NU950_RS08580 (1368682) 1368682..1369233 + 552 WP_000102564.1 maltose O-acetyltransferase -
NU950_RS08585 (1369349) 1369349..1369819 + 471 WP_000136192.1 YlaC family protein -
NU950_RS08590 (1369983) 1369983..1371533 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NU950_RS08595 (1371575) 1371575..1371928 - 354 WP_000878141.1 DUF1428 family protein -
NU950_RS08605 (1372307) 1372307..1372618 + 312 WP_000409911.1 MGMT family protein -
NU950_RS08610 (1372649) 1372649..1373221 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253940 WP_001291435.1 NZ_CP102675:1368293-1368511 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT253940 WP_000344800.1 NZ_CP102675:1367893-1368267 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References