Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 381202..381840 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag NU950_RS03810 Protein ID WP_000813794.1
Coordinates 381664..381840 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NU950_RS03805 Protein ID WP_001270286.1
Coordinates 381202..381618 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS03785 (376354) 376354..377295 - 942 WP_072649490.1 ABC transporter permease -
NU950_RS03790 (377296) 377296..378309 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
NU950_RS03795 (378327) 378327..379472 - 1146 WP_000047456.1 ABC transporter substrate-binding protein -
NU950_RS03800 (379717) 379717..381123 - 1407 WP_000760592.1 PLP-dependent aminotransferase family protein -
NU950_RS03805 (381202) 381202..381618 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NU950_RS03810 (381664) 381664..381840 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NU950_RS03815 (382062) 382062..382292 + 231 WP_000494244.1 YncJ family protein -
NU950_RS03820 (382384) 382384..384345 - 1962 WP_001593323.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NU950_RS03825 (384418) 384418..384954 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
NU950_RS03830 (385046) 385046..386221 + 1176 WP_001236215.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T253939 WP_000813794.1 NZ_CP102675:c381840-381664 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT253939 WP_001270286.1 NZ_CP102675:c381618-381202 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References