Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 289099..290687 Replicon chromosome
Accession NZ_CP102675
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name hipA Uniprot ID E0IX85
Locus tag NU950_RS03400 Protein ID WP_001125454.1
Coordinates 289365..290687 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NU950_RS03395 Protein ID WP_001296726.1
Coordinates 289099..289365 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS03390 (284634) 284634..288890 + 4257 Protein_288 ECSE_1600 family autotransporter -
NU950_RS03395 (289099) 289099..289365 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NU950_RS03400 (289365) 289365..290687 + 1323 WP_001125454.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NU950_RS03405 (291000) 291000..291208 + 209 Protein_291 AraC family transcriptional regulator -
NU950_RS03410 (291640) 291640..292203 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
NU950_RS03415 (292564) 292564..293274 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 289099..305188 16089
- flank IS/Tn - - 283882..284259 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49307.90 Da        Isoelectric Point: 8.8753

>T253938 WP_001125454.1 NZ_CP102675:289365-290687 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT253938 WP_001296726.1 NZ_CP102675:289099-289365 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0IX85

Antitoxin

Source ID Structure

References