Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 90909..91534 Replicon plasmid pXH987-CTX
Accession NZ_CP102673
Organism Escherichia coli strain XH987

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NU950_RS00900 Protein ID WP_000911313.1
Coordinates 90909..91307 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag NU950_RS00905 Protein ID WP_000450520.1
Coordinates 91307..91534 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NU950_RS00885 (87234) 87234..87731 + 498 WP_000605857.1 entry exclusion protein -
NU950_RS00890 (87763) 87763..88494 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
NU950_RS00895 (88747) 88747..90900 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
NU950_RS00900 (90909) 90909..91307 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
NU950_RS00905 (91307) 91307..91534 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtB / blaTEM-1B / sitABCD / blaCTX-M-65 / fosA3 / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / mph(A) / sul1 / qacE / aadA5 / aac(3)-IId iroB / iroC / iroD / iroE / iroN / iucA / iucB / iucC / iucD / iutA 1..167177 167177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T253933 WP_000911313.1 NZ_CP102673:c91307-90909 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT253933 WP_000450520.1 NZ_CP102673:c91534-91307 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References