Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4443723..4444504 | Replicon | chromosome |
| Accession | NZ_CP102669 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | NUW86_RS21920 | Protein ID | WP_000626099.1 |
| Coordinates | 4443723..4444214 (-) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | NUW86_RS21925 | Protein ID | WP_001110452.1 |
| Coordinates | 4444211..4444504 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NUW86_RS21885 (4439718) | 4439718..4440293 | + | 576 | WP_001188509.1 | transcriptional regulator | - |
| NUW86_RS21895 (4440564) | 4440564..4440641 | - | 78 | Protein_4282 | helix-turn-helix domain-containing protein | - |
| NUW86_RS21900 (4440732) | 4440732..4441064 | - | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| NUW86_RS21905 (4441136) | 4441136..4441513 | + | 378 | WP_000916345.1 | EthD family reductase | - |
| NUW86_RS21910 (4442546) | 4442546..4442620 | + | 75 | Protein_4285 | porin family protein | - |
| NUW86_RS21915 (4442723) | 4442723..4443475 | + | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| NUW86_RS21920 (4443723) | 4443723..4444214 | - | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| NUW86_RS21925 (4444211) | 4444211..4444504 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| NUW86_RS21930 (4444821) | 4444821..4445042 | + | 222 | WP_001576552.1 | hypothetical protein | - |
| NUW86_RS21935 (4445307) | 4445307..4446182 | + | 876 | WP_000921674.1 | AraC family transcriptional regulator | - |
| NUW86_RS21940 (4446179) | 4446179..4446466 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| NUW86_RS21945 (4446489) | 4446489..4446704 | + | 216 | WP_001595136.1 | hypothetical protein | - |
| NUW86_RS21950 (4446712) | 4446712..4446981 | + | 270 | WP_010989096.1 | hypothetical protein | - |
| NUW86_RS21955 (4447275) | 4447275..4448180 | - | 906 | WP_001268200.1 | YjiK family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T253923 WP_000626099.1 NZ_CP102669:c4444214-4443723 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT253923 WP_001110452.1 NZ_CP102669:c4444504-4444211 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |