Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4315097..4315613 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag NUW86_RS21255 Protein ID WP_000220578.1
Coordinates 4315097..4315381 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NUW86_RS21260 Protein ID WP_000212724.1
Coordinates 4315371..4315613 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS21240 (4310309) 4310309..4311961 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
NUW86_RS21245 (4312370) 4312370..4314508 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NUW86_RS21250 (4314629) 4314629..4315093 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NUW86_RS21255 (4315097) 4315097..4315381 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUW86_RS21260 (4315371) 4315371..4315613 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUW86_RS21265 (4315691) 4315691..4317604 - 1914 WP_001212137.1 BglG family transcription antiterminator -
NUW86_RS21270 (4317621) 4317621..4318361 - 741 WP_000779263.1 KDGP aldolase family protein -
NUW86_RS21275 (4318358) 4318358..4319476 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NUW86_RS21280 (4319460) 4319460..4320593 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T253922 WP_000220578.1 NZ_CP102669:c4315381-4315097 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT253922 WP_000212724.1 NZ_CP102669:c4315613-4315371 [Salmonella enterica subsp. enterica serovar Typhimurium]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References