Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4220836..4221412 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NUW86_RS20855 Protein ID WP_001131963.1
Coordinates 4221125..4221412 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NUW86_RS20850 Protein ID WP_000063142.1
Coordinates 4220836..4221138 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS20835 (4217346) 4217346..4219496 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
NUW86_RS20840 (4219591) 4219591..4219794 + 204 WP_000460616.1 YbdD/YjiX family protein -
NUW86_RS20845 (4219805) 4219805..4220761 + 957 WP_000187839.1 GTPase -
NUW86_RS20850 (4220836) 4220836..4221138 - 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NUW86_RS20855 (4221125) 4221125..4221412 - 288 WP_001131963.1 BrnT family toxin Toxin
NUW86_RS20860 (4221681) 4221681..4222595 - 915 WP_000290512.1 restriction endonuclease -
NUW86_RS20865 (4222793) 4222793..4226302 + 3510 WP_001043484.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T253921 WP_001131963.1 NZ_CP102669:c4221412-4221125 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT253921 WP_000063142.1 NZ_CP102669:c4221138-4220836 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References