Detailed information of TA system TA025392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1244028..1244683
• Replicon: chromosome
• Accession: NC_015675
• Organism: Mesorhizobium opportunistum WSM2075

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: F7YED5
• Locus tag: MESOP_RS05915
• Protein ID: WP_013892419.1
• Coordinates: 1244028..1244429 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: X6DRQ6
• Locus tag: MESOP_RS05920
• Protein ID: WP_013892420.1
• Coordinates: 1244429..1244683 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MESOP_RS05890	1239165..1239437	+	273	WP_013892414.1	usg protein	-
MESOP_RS05895	1239499..1240533	-	1035	WP_013892415.1	aldo/keto reductase	-
MESOP_RS05900	1240576..1241757	-	1182	WP_041164541.1	MFS transporter	-
MESOP_RS05905	1241882..1242784	+	903	WP_013892417.1	LysR family transcriptional regulator	-
MESOP_RS05910	1242835..1243884	-	1050	WP_013892418.1	aldo/keto reductase	-
MESOP_RS05915	1244028..1244429	-	402	WP_013892419.1	type II toxin-antitoxin system VapC family toxin	Toxin
MESOP_RS05920	1244429..1244683	-	255	WP_013892420.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MESOP_RS05925	1244764..1245426	-	663	WP_013892421.1	YggS family pyridoxal phosphate-dependent enzyme	-
MESOP_RS05930	1245583..1248207	+	2625	WP_013892422.1	leucine--tRNA ligase	-
MESOP_RS05935	1248194..1248787	+	594	WP_013892423.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-54)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14797.81 Da
• Isoelectric Point: 4.7402

>T25392 WP_013892419.1 NC_015675:c1244429-1244028 [Mesorhizobium opportunistum WSM2075]
MYLLDTNIVSDVQRRLPKPTDWLASVDPTSVNLSVTTLGEIERGITKLRKVDSEKATRLDLWLRELRRDNADRILAVTED
VALAWGRITAGRTRGSADTLIAATALVHDLILVTRNTADFDDTGVTVLDPWDV

Nucleotide

• Length: 402 bp

>T25392 NC_015675:c1244429-1244028 [Mesorhizobium opportunistum WSM2075]
ATGTATCTGCTCGACACGAACATCGTTTCGGATGTGCAGAGGCGGCTGCCCAAGCCGACTGACTGGCTGGCATCGGTGGA
CCCGACATCAGTCAATCTCAGCGTCACTACGCTTGGAGAGATCGAGCGTGGGATCACCAAGCTGCGCAAGGTCGACTCCG
AAAAGGCAACACGCCTCGATCTGTGGCTGCGGGAGCTTCGGCGGGACAATGCGGACCGTATTCTTGCCGTTACGGAAGAT
GTCGCGTTGGCTTGGGGCCGTATCACGGCCGGCCGCACAAGAGGCAGCGCCGATACCCTCATCGCGGCAACCGCCCTTGT
CCATGATCTTATTCTGGTGACGCGCAACACCGCCGACTTCGATGATACAGGCGTGACGGTGCTCGATCCCTGGGACGTCT
AA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9617.84 Da
• Isoelectric Point: 7.0133

>AT25392 WP_013892420.1 NC_015675:c1244683-1244429 [Mesorhizobium opportunistum WSM2075]
MNWHLQDAKNNFSKVVQRARSEGPQTVTLRGERAAVVLSAEDYDRLAGKKKSLAEYLLTGPVWDDDFAEEVNRRPKTMIR
DVDL

Nucleotide

• Length: 255 bp

>AT25392 NC_015675:c1244683-1244429 [Mesorhizobium opportunistum WSM2075]
ATGAACTGGCACCTTCAGGACGCGAAGAACAATTTTTCCAAGGTGGTTCAGCGTGCGCGAAGCGAGGGACCGCAGACAGT
GACGTTGCGTGGCGAGCGTGCCGCAGTGGTTCTCTCCGCCGAGGACTACGACCGTCTCGCTGGAAAGAAAAAGTCGCTGG
CGGAGTACCTTTTGACAGGTCCTGTCTGGGACGATGATTTCGCCGAAGAGGTCAACCGTCGCCCGAAAACGATGATCCGG
GACGTCGATCTCTGA

Structures

Toxin

• AlphaFold DB: F7YED5

Antitoxin

• AlphaFold DB: X6DRQ6