Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3620183..3620803 Replicon chromosome
Accession NZ_CP102669
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain ATCC 14028

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NUW86_RS18095 Protein ID WP_001280991.1
Coordinates 3620585..3620803 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NUW86_RS18090 Protein ID WP_000344807.1
Coordinates 3620183..3620557 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW86_RS18080 (3615322) 3615322..3616515 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NUW86_RS18085 (3616538) 3616538..3619687 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NUW86_RS18090 (3620183) 3620183..3620557 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NUW86_RS18095 (3620585) 3620585..3620803 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NUW86_RS18100 (3620982) 3620982..3621533 + 552 WP_001278792.1 maltose O-acetyltransferase -
NUW86_RS18105 (3621650) 3621650..3622120 + 471 WP_000136181.1 YlaC family protein -
NUW86_RS18110 (3622176) 3622176..3622316 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NUW86_RS18115 (3622322) 3622322..3622582 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NUW86_RS18120 (3622807) 3622807..3624357 + 1551 WP_000213139.1 EAL domain-containing protein -
NUW86_RS18130 (3624588) 3624588..3624977 + 390 WP_000961285.1 MGMT family protein -
NUW86_RS18135 (3625010) 3625010..3625579 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T253918 WP_001280991.1 NZ_CP102669:3620585-3620803 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT253918 WP_000344807.1 NZ_CP102669:3620183-3620557 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References