Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 102900..104404 Replicon plasmid pNIN3
Accession NZ_CP102668
Organism Sphingobium sp. JS3065

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag NUH86_RS24490 Protein ID WP_267253223.1
Coordinates 102900..104174 (-) Length 425 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag NUH86_RS24495 Protein ID WP_017503541.1
Coordinates 104171..104404 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUH86_RS24475 (NUH86_24480) 98423..99838 + 1416 WP_267253037.1 ISNCY family transposase -
NUH86_RS24480 (NUH86_24485) 100100..101101 + 1002 WP_267253222.1 IS30 family transposase -
NUH86_RS24485 (NUH86_24490) 101295..102703 + 1409 Protein_92 ISNCY family transposase -
NUH86_RS24490 (NUH86_24495) 102900..104174 - 1275 WP_267253223.1 type II toxin-antitoxin system HipA family toxin Toxin
NUH86_RS24495 (NUH86_24500) 104171..104404 - 234 WP_017503541.1 helix-turn-helix transcriptional regulator Antitoxin
NUH86_RS24500 (NUH86_24505) 104530..105132 - 603 WP_267253224.1 DUF6088 family protein -
NUH86_RS24505 (NUH86_24510) 105278..106384 - 1107 WP_267253225.1 relaxase/mobilization nuclease domain-containing protein -
NUH86_RS24510 (NUH86_24515) 106377..106913 - 537 WP_267253226.1 plasmid mobilization relaxosome protein MobC -
NUH86_RS24515 (NUH86_24520) 107164..108096 - 933 WP_267253227.1 ParB/RepB/Spo0J family partition protein -
NUH86_RS24520 (NUH86_24525) 108096..108860 - 765 WP_267253228.1 ParA family protein -
NUH86_RS24525 (NUH86_24530) 108874..109050 - 177 WP_267253229.1 hypothetical protein -
NUH86_RS24530 (NUH86_24535) 109236..109325 - 90 Protein_101 DUF3768 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..148600 148600


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-107)

Antitoxin

Transcription regulator, HipB-like

(6-62)


Sequences

Toxin        


Download         Length: 425 a.a.        Molecular weight: 45180.87 Da        Isoelectric Point: 5.5137

>T253906 WP_267253223.1 NZ_CP102668:c104174-102900 [Sphingobium sp. JS3065]
MTADILERLVVWSDQRIAGELSIDRGGAMHFIYADDWLADPAAGPLSHALPKQAEPFGDALCKAVFGGLLPEEGQRTAIA
RALGVSPDNPFRLLAALGGDVAGALAFLPEGEKPPLPPEGEPPPALDDAELAVLIGRLPRVPMLAGEGGARLSLAGAQGK
LPVVLAEGRVAVPRVGEPSTHLIKPEPDRFPGLAANEAFCLALARAVGLDAAMAEWREVADKPYLLVTRYDRLDREGHTI
RLHQEDFAQAQGVPSNRKYASEGGPTFRDCFALVRQATTRPAREVLKLADAAIFNAIIGNADAHAKNYSLLRQSKGEVVL
APLYDLVATHMWPELSAKLAMRFGRAATLEEIDAGSFERFAGDTGLALPFLRRRVAALAARVQEVISGGVTVRGLDDSAC
LGELPSIVLDRAARLALKAQSLAY

Download         Length: 1275 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8319.81 Da        Isoelectric Point: 6.2620

>AT253906 WP_017503541.1 NZ_CP102668:c104404-104171 [Sphingobium sp. JS3065]
MLDMTMIGQIVRDERKEMGLRQDELAAASGVGLRFIVELERGKATAQIGKVITVLAALGCELQIRRPDGIVIAGQPT

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References