Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 327649..328307 Replicon chromosome
Accession NZ_CP102665
Organism Sphingobium sp. JS3065

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUH86_RS18900 Protein ID WP_267252858.1
Coordinates 327870..328307 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1H7CAD6
Locus tag NUH86_RS18895 Protein ID WP_066860643.1
Coordinates 327649..327873 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUH86_RS18865 (NUH86_18870) 322734..322934 - 201 WP_267252852.1 hypothetical protein -
NUH86_RS18870 (NUH86_18875) 323650..323925 + 276 WP_267252853.1 HU family DNA-binding protein -
NUH86_RS18875 (NUH86_18880) 324591..325349 + 759 WP_267252854.1 LuxR family transcriptional regulator -
NUH86_RS18880 (NUH86_18885) 325633..326247 + 615 WP_267252855.1 acyl-homoserine-lactone synthase -
NUH86_RS18885 (NUH86_18890) 326260..327165 + 906 WP_267252856.1 phytanoyl-CoA dioxygenase family protein -
NUH86_RS18890 (NUH86_18895) 327182..327580 + 399 WP_267252857.1 MarR family winged helix-turn-helix transcriptional regulator -
NUH86_RS18895 (NUH86_18900) 327649..327873 + 225 WP_066860643.1 CopG family transcriptional regulator Antitoxin
NUH86_RS18900 (NUH86_18905) 327870..328307 + 438 WP_267252858.1 PIN domain-containing protein Toxin
NUH86_RS18905 (NUH86_18910) 328307..329227 + 921 WP_267252998.1 nucleotidyltransferase domain-containing protein -
NUH86_RS18910 (NUH86_18915) 329604..330416 + 813 WP_267252859.1 DNA-binding response regulator -
NUH86_RS18915 (NUH86_18920) 330409..330996 + 588 WP_267252860.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 221345..462026 240681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15707.84 Da        Isoelectric Point: 6.6936

>T253904 WP_267252858.1 NZ_CP102665:327870-328307 [Sphingobium sp. JS3065]
VTYLLDVNVLVALIDPNHVGHDAAHHWFESIGARAWATCPITENGVIRIVGNVKYPSTPGSPAEVARIIGQMRQLPGHSF
WADDISLLSDERVDESRLLTSAQVTDTYLLALAVAHDGKLATFDRRLSPRAVSGGKAALHLIGHQ

Download         Length: 438 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7944.09 Da        Isoelectric Point: 7.0120

>AT253904 WP_066860643.1 NZ_CP102665:327649-327873 [Sphingobium sp. JS3065]
MRTTLVIDDDVMEAARAIAEHQNRSIGQVVSDLARRSLRAPEAARSRNGIALLAAKPGVVVTPEIVNALRDEAP

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1H7CAD6

References