Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3192538..3193199 Replicon chromosome
Accession NZ_CP102664
Organism Sphingobium sp. JS3065

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUH86_RS15570 Protein ID WP_267252163.1
Coordinates 3192810..3193199 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NUH86_RS15565 Protein ID WP_267250326.1
Coordinates 3192538..3192801 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUH86_RS15540 (NUH86_15545) 3189053..3189451 + 399 WP_267252202.1 hypothetical protein -
NUH86_RS15545 (NUH86_15550) 3189542..3189970 - 429 Protein_3057 DNA polymerase Y family protein -
NUH86_RS15550 (NUH86_15555) 3190197..3190976 - 780 WP_267250323.1 protein ImuA -
NUH86_RS15555 (NUH86_15560) 3191078..3191500 - 423 WP_267250324.1 DUF1810 domain-containing protein -
NUH86_RS15560 (NUH86_15565) 3191500..3192117 - 618 WP_267250325.1 SOS response-associated peptidase -
NUH86_RS15565 (NUH86_15570) 3192538..3192801 + 264 WP_267250326.1 antitoxin Antitoxin
NUH86_RS15570 (NUH86_15575) 3192810..3193199 + 390 WP_267252163.1 type II toxin-antitoxin system VapC family toxin Toxin
NUH86_RS15575 (NUH86_15580) 3193430..3194014 + 585 WP_267250327.1 SOS response-associated peptidase family protein -
NUH86_RS15580 (NUH86_15585) 3194035..3194610 + 576 WP_267252164.1 alpha-ketoglutarate-dependent dioxygenase AlkB -
NUH86_RS15585 (NUH86_15590) 3194724..3194918 + 195 WP_267250328.1 type II toxin-antitoxin system VapB family antitoxin -
NUH86_RS15590 (NUH86_15595) 3194966..3196498 + 1533 WP_267250329.1 Fic family protein -
NUH86_RS15595 (NUH86_15600) 3196662..3198032 + 1371 WP_013039223.1 IS1380-like element ISSp1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3196662..3198032 1370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

SpoVT-AbrB domain

(16-53)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13642.58 Da        Isoelectric Point: 5.5791

>T253902 WP_267252163.1 NZ_CP102664:3192810-3193199 [Sphingobium sp. JS3065]
MLDTNIVSDLLRHPDGSAAKRIAEVGPDAICVSIITAAELRYGCARKGSAKLLAHVEAILESVQVLALDVPADAEYGGIR
AEHEAAGKPIGPNDLFIAAHAYAAGAILVTNNTGEFSRIRGLQVENWIR

Download         Length: 390 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9988.38 Da        Isoelectric Point: 5.1358

>AT253902 WP_267250326.1 NZ_CP102664:3192538-3192801 [Sphingobium sp. JS3065]
MPHPQSYSEPREAKLFRNNKSQAVRIPADFEMPGDRVNIYRDGNRLIIEPVRRKNLLEVLAGLDPLGPEDQFPDVHETLL
PAKEIDL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References