253898

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1439965..1440884 Replicon chromosome
Accession NZ_CP102663
Organism Bacillus sp. BAC

Toxin (Protein)


Gene name spoIISA Uniprot ID T5HIF3
Locus tag NR984_RS07420 Protein ID WP_003180879.1
Coordinates 1440138..1440884 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID T5HT37
Locus tag NR984_RS07415 Protein ID WP_003180877.1
Coordinates 1439965..1440138 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR984_RS07390 (NR984_07390) 1435390..1436487 + 1098 WP_003180867.1 mannonate dehydratase -
NR984_RS07395 (NR984_07395) 1436463..1437311 + 849 WP_003180869.1 SDR family oxidoreductase -
NR984_RS07400 (NR984_07400) 1437338..1438351 + 1014 WP_011197810.1 zinc-binding alcohol dehydrogenase family protein -
NR984_RS07405 (NR984_07405) 1438404..1439675 + 1272 WP_011197811.1 MFS transporter -
NR984_RS07410 (NR984_07410) 1439738..1439869 - 132 WP_003180875.1 hypothetical protein -
NR984_RS07415 (NR984_07415) 1439965..1440138 - 174 WP_003180877.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NR984_RS07420 (NR984_07420) 1440138..1440884 - 747 WP_003180879.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NR984_RS07425 (NR984_07425) 1440995..1441993 - 999 WP_009328723.1 inorganic phosphate transporter -
NR984_RS07430 (NR984_07430) 1442006..1442623 - 618 WP_003180884.1 DUF47 domain-containing protein -
NR984_RS07435 (NR984_07435) 1442955..1444712 + 1758 WP_003180886.1 gamma-glutamyltransferase -
NR984_RS07440 (NR984_07440) 1444841..1445485 + 645 WP_009328721.1 YesL family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-57)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29391.80 Da        Isoelectric Point: 4.5367

>T253898 WP_003180879.1 NZ_CP102663:c1440884-1440138 [Bacillus sp. BAC]
MLLFYQFLVWLIVLALALYVAAVWRFEKQLAEKTVAIRKTWYLLYVIGAVIYWTHDPQSIFTNPLHYLIVAVFFTLTDAF
IFLNAYFKKLGSSELATDTRMLLEENNDLLHTYQNRLKTFQYLLKNEPIHIYYGNIEAYAEGIEKLIKRFAEKMNISAAL
CEYNSEESKDHLLEHMENRFDVQEKLDRKDVYYEENGKMVLIPFSIHDFDYVMKLTSEDLVTEFDYLLFTSLTSIYDLLL
PNEEEGDD

Download         Length: 747 bp

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6945.04 Da        Isoelectric Point: 10.9186

>AT253898 WP_003180877.1 NZ_CP102663:c1440138-1439965 [Bacillus sp. BAC]
MEPAFQQDQESVKKRLAFKMFKRQSKTNIAKYEVSPHTERIFRQNERLIGEYKRKKA

Download         Length: 174 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T5HIF3

Antitoxin

Source ID Structure
AlphaFold DB T5HT37

References