Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 864044..864673 Replicon chromosome
Accession NZ_CP102627
Organism Listeria innocua strain F4078

Toxin (Protein)


Gene name pemK Uniprot ID Q92DC7
Locus tag NVV61_RS04190 Protein ID WP_010990666.1
Coordinates 864326..864673 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1GC21
Locus tag NVV61_RS04185 Protein ID WP_003761302.1
Coordinates 864044..864322 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NVV61_RS04165 (NVV61_04165) 859342..860826 + 1485 WP_187984061.1 PH domain-containing protein -
NVV61_RS04170 (NVV61_04170) 860976..862355 + 1380 WP_070753404.1 protoporphyrinogen oxidase -
NVV61_RS04175 (NVV61_04175) 862357..862713 + 357 WP_003761296.1 holo-ACP synthase -
NVV61_RS04180 (NVV61_04180) 862732..863838 + 1107 WP_187984062.1 alanine racemase -
NVV61_RS04185 (NVV61_04185) 864044..864322 + 279 WP_003761302.1 CopG family ribbon-helix-helix protein Antitoxin
NVV61_RS04190 (NVV61_04190) 864326..864673 + 348 WP_010990666.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NVV61_RS04195 (NVV61_04195) 864925..865761 + 837 WP_003771126.1 STAS domain-containing protein -
NVV61_RS04200 (NVV61_04200) 865767..866123 + 357 WP_187984063.1 STAS domain-containing protein -
NVV61_RS04205 (NVV61_04205) 866126..866536 + 411 WP_010990667.1 anti-sigma regulatory factor -
NVV61_RS04210 (NVV61_04210) 866553..867557 + 1005 WP_045553450.1 PP2C family protein-serine/threonine phosphatase -
NVV61_RS04215 (NVV61_04215) 867707..868051 + 345 WP_187997213.1 anti sigma b factor antagonist RsbV -
NVV61_RS04220 (NVV61_04220) 868035..868508 + 474 WP_003761314.1 anti-sigma B factor RsbW -
NVV61_RS04225 (NVV61_04225) 868486..869265 + 780 WP_010990669.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.85 Da        Isoelectric Point: 6.4735

>T253895 WP_010990666.1 NZ_CP102627:864326-864673 [Listeria innocua]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNQALEVSLGVVEF

Download         Length: 348 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.13 Da        Isoelectric Point: 4.2980

>AT253895 WP_003761302.1 NZ_CP102627:864044-864322 [Listeria innocua]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7E4N0

Antitoxin

Source ID Structure
AlphaFold DB H1GC21

References