Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 939015..939662 Replicon chromosome
Accession NZ_CP102606
Organism Thermus sp. PS18

Toxin (Protein)


Gene name vapC Uniprot ID E8PLT6
Locus tag KQ693_RS05310 Protein ID WP_015716453.1
Coordinates 939015..939401 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID E8PLT7
Locus tag KQ693_RS05315 Protein ID WP_015716454.1
Coordinates 939402..939662 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KQ693_RS05275 (KQ693_05275) 934047..935120 + 1074 WP_015716446.1 radical SAM protein -
KQ693_RS05280 (KQ693_05280) 935157..935546 + 390 WP_019551701.1 NADH-quinone oxidoreductase subunit 15 -
KQ693_RS05285 (KQ693_05285) 935543..935941 - 399 WP_015716448.1 PaaI family thioesterase -
KQ693_RS05290 (KQ693_05290) 935972..937093 - 1122 WP_267262146.1 radical SAM family heme chaperone HemW -
KQ693_RS05295 (KQ693_05295) 937094..937486 - 393 WP_019551703.1 HEPN domain-containing protein -
KQ693_RS05300 (KQ693_05300) 937476..937793 - 318 WP_019551704.1 nucleotidyltransferase domain-containing protein -
KQ693_RS05305 (KQ693_05305) 937798..939018 - 1221 WP_267262147.1 glycerate kinase -
KQ693_RS05310 (KQ693_05310) 939015..939401 - 387 WP_015716453.1 type II toxin-antitoxin system VapC family toxin Toxin
KQ693_RS05315 (KQ693_05315) 939402..939662 - 261 WP_015716454.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KQ693_RS05320 (KQ693_05320) 939670..940956 - 1287 WP_015716455.1 glycolate oxidase subunit GlcF -
KQ693_RS05325 (KQ693_05325) 940961..942007 - 1047 WP_015716456.1 FAD-binding protein -
KQ693_RS05330 (KQ693_05330) 942000..943403 - 1404 WP_267262148.1 FAD-linked oxidase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-65)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14014.22 Da        Isoelectric Point: 5.6564

>T253893 WP_015716453.1 NZ_CP102606:c939401-939015 [Thermus sp. PS18]
MVLDTSAVLAILLREPGYETLLQRIVRGEPPKIGAPTLAEAGIVVVARLGFSYLHLLYELLEALGAEVIPFTEKHAREAI
RAYKEFGRAQHPAGLNFGDCLSYATARVEGMPLLYKGDDFAQTDLGQK

Download         Length: 387 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9998.54 Da        Isoelectric Point: 6.3992

>AT253893 WP_015716454.1 NZ_CP102606:c939662-939402 [Thermus sp. PS18]
MAFTIRDKDVERLVEEVTRLTGESRAEAVRKALEMRLAELKPRQGLQNLLRTLEDKIWSKIPPEYLDKPLSQEETERLLG
YGPKGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References