Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4220855..4222434 Replicon chromosome
Accession NZ_CP102604
Organism Pantoea sp. SOD02

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NR302_RS19645 Protein ID WP_258144232.1
Coordinates 4220855..4222174 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NR302_RS19650 Protein ID WP_061719987.1
Coordinates 4222174..4222434 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR302_RS19620 (NR302_19620) 4216368..4217030 - 663 WP_258144230.1 6-phosphogluconate phosphatase -
NR302_RS19625 (NR302_19625) 4217182..4218495 + 1314 WP_258144231.1 NCS2 family permease -
NR302_RS19630 (NR302_19630) 4218524..4219270 - 747 WP_008105307.1 4'-phosphopantetheinyl transferase superfamily protein -
NR302_RS19635 (NR302_19635) 4219566..4220075 + 510 WP_061719984.1 flavin reductase family protein -
NR302_RS19640 (NR302_19640) 4220122..4220712 - 591 WP_154156954.1 malonic semialdehyde reductase -
NR302_RS19645 (NR302_19645) 4220855..4222174 - 1320 WP_258144232.1 type II toxin-antitoxin system HipA family toxin Toxin
NR302_RS19650 (NR302_19650) 4222174..4222434 - 261 WP_061719987.1 helix-turn-helix domain-containing protein Antitoxin
NR302_RS19655 (NR302_19655) 4222592..4223956 - 1365 WP_008105304.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
NR302_RS19660 (NR302_19660) 4224041..4225687 - 1647 WP_258144233.1 membrane protein insertase YidC -
NR302_RS19665 (NR302_19665) 4225690..4225947 - 258 WP_007893564.1 membrane protein insertion efficiency factor YidD -
NR302_RS19670 (NR302_19670) 4225911..4226270 - 360 WP_036648555.1 ribonuclease P protein component -
NR302_RS19675 (NR302_19675) 4226285..4226425 - 141 WP_003849659.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49182.42 Da        Isoelectric Point: 5.3319

>T253891 WP_258144232.1 NZ_CP102604:c4222174-4220855 [Pantoea sp. SOD02]
MTELDVYMNGYKVGIFARAATGAHQFCYLEEWLNQPGSRPISLSMPLRHPPYTGSEVYNFFDNLLPDNIEIRNRILTRHQ
AESSQQFDLLYKIGADTVGALQLLAHDSPPRDVQSIHYKALDDAELEKILTGYQAGAPLGMIEEIDDFRISLAGAQEKTA
LLRINDKWCLPQGTTPTTHILKLPIGKIQSHSYSIDLTGSVENEWLCTLIAKEFGLSVPDCFIVRVGDVKALAVERFDRK
YAADGSWIMRLPQEDFCQVLNVPAAAKYETQGGPGIAQIMDYLLSSVAVEQDRYDFMKAQVLFWLLAATDGHAKNFSIFI
EAEGRFRLAPFYDILSVYPMIGGKGLNIRDAKLAMGLKGSKGKKYAVEQIFPRHFIETAKAVGFDPAAMQRVLRELSESV
DDVIERVCQQLPEDFPPSIQATILDGLKMRATRLKPEQD

Download         Length: 1320 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9800.09 Da        Isoelectric Point: 10.0971

>AT253891 WP_061719987.1 NZ_CP102604:c4222434-4222174 [Pantoea sp. SOD02]
MKITNAKQLSAYLKDVRQSEHLSQGKVANKVGIRQDTVSNFELQPGTTKLDTFFRILAALNLELEIKPRGNSDHTQQKSS
GWKEEW

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References