Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 392398..393096 Replicon chromosome
Accession NZ_CP102604
Organism Pantoea sp. SOD02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NR302_RS01760 Protein ID WP_073980697.1
Coordinates 392398..392574 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NR302_RS01765 Protein ID WP_154154690.1
Coordinates 392692..393096 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NR302_RS01745 (NR302_01745) 387885..388211 - 327 WP_008109989.1 DUF485 domain-containing protein -
NR302_RS01750 (NR302_01750) 388358..390313 - 1956 WP_258144379.1 acetate--CoA ligase -
NR302_RS01755 (NR302_01755) 390895..392196 + 1302 WP_061718358.1 glutamate/aspartate:proton symporter GltP -
NR302_RS01760 (NR302_01760) 392398..392574 + 177 WP_073980697.1 type II toxin-antitoxin system HicA family toxin Toxin
NR302_RS01765 (NR302_01765) 392692..393096 + 405 WP_154154690.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NR302_RS01770 (NR302_01770) 393236..394147 + 912 WP_154154687.1 N-acetylmuramic acid 6-phosphate etherase -
NR302_RS01775 (NR302_01775) 394147..395577 + 1431 WP_154154877.1 PTS N-acetylmuramic acid transporter subunit IIBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6851.18 Da        Isoelectric Point: 10.9595

>T253887 WP_073980697.1 NZ_CP102604:392398-392574 [Pantoea sp. SOD02]
MSSRELIRMLLERGWVLDRVKGSHHIFVRMDKPYHISLPHPEKDLATGTVRKLLKLMN

Download         Length: 177 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14708.27 Da        Isoelectric Point: 4.4077

>AT253887 WP_154154690.1 NZ_CP102604:392692-393096 [Pantoea sp. SOD02]
MRFPVYLHKTESNTYSGFVPDVVGCFFAGETVDDALTDASAAIDAHVESSTDAGYEVPVATSIETHIEDENCQGGYWAFV
DIDLSRYEGKAVKLNITLPQNLLTKIDSYVDHHREYGSRSGFLAALARKELANA

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References