Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1205694..1206611 Replicon chromosome
Accession NZ_CP102603
Organism Bacillus amyloliquefaciens strain MBLB0692

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NUW85_RS05275 Protein ID WP_025851786.1
Coordinates 1205694..1206440 (+) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NUW85_RS05280 Protein ID WP_003154807.1
Coordinates 1206441..1206611 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUW85_RS05255 (NUW85_05255) 1201086..1202036 - 951 WP_015388352.1 ring-cleaving dioxygenase -
NUW85_RS05260 (NUW85_05260) 1202360..1203676 + 1317 WP_003154801.1 amino acid permease -
NUW85_RS05265 (NUW85_05265) 1203962..1204579 + 618 WP_003154804.1 DUF47 domain-containing protein -
NUW85_RS05270 (NUW85_05270) 1204592..1205590 + 999 WP_003154805.1 inorganic phosphate transporter -
NUW85_RS05275 (NUW85_05275) 1205694..1206440 + 747 WP_025851786.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NUW85_RS05280 (NUW85_05280) 1206441..1206611 + 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NUW85_RS05285 (NUW85_05285) 1206708..1206833 + 126 WP_003154809.1 hypothetical protein -
NUW85_RS05290 (NUW85_05290) 1206869..1207747 - 879 WP_014304858.1 N-acetylmuramoyl-L-alanine amidase -
NUW85_RS05295 (NUW85_05295) 1207761..1208024 - 264 WP_003154813.1 phage holin -
NUW85_RS05300 (NUW85_05300) 1208038..1208301 - 264 WP_003154815.1 hemolysin XhlA family protein -
NUW85_RS05305 (NUW85_05305) 1208353..1209114 - 762 WP_058905961.1 hypothetical protein -
NUW85_RS05310 (NUW85_05310) 1209171..1209368 - 198 WP_003154819.1 XkdX family protein -
NUW85_RS05315 (NUW85_05315) 1209374..1209745 - 372 WP_014304856.1 XkdW family protein -
NUW85_RS05320 (NUW85_05320) 1209758..1211380 - 1623 WP_058905960.1 pyocin knob domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29048.53 Da        Isoelectric Point: 4.7003

>T253884 WP_025851786.1 NZ_CP102603:1205694-1206440 [Bacillus amyloliquefaciens]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVVGAMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYGEKMNVTASL
CEYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQDRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT253884 WP_003154807.1 NZ_CP102603:1206441-1206611 [Bacillus amyloliquefaciens]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References