Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1218647..1219247 Replicon chromosome
Accession NZ_CP102602
Organism Thermococcus sp. 813A4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUS69_RS07020 Protein ID WP_258085026.1
Coordinates 1218647..1219012 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NUS69_RS07025 Protein ID WP_258085027.1
Coordinates 1219026..1219247 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUS69_RS07000 1214803..1216269 - 1467 WP_258083130.1 S-layer protein -
NUS69_RS07005 1216334..1216873 + 540 WP_258083131.1 DUF2391 family protein -
NUS69_RS07010 1216874..1217908 + 1035 WP_258083132.1 DUF3226 domain-containing protein -
NUS69_RS07015 1217949..1218650 + 702 WP_258085025.1 HAD family hydrolase -
NUS69_RS07020 1218647..1219012 - 366 WP_258085026.1 type II toxin-antitoxin system VapC family toxin Toxin
NUS69_RS07025 1219026..1219247 - 222 WP_258085027.1 hypothetical protein Antitoxin
NUS69_RS07030 1219299..1221626 - 2328 WP_258083133.1 DNA polymerase -
NUS69_RS07035 1221623..1221892 - 270 WP_258083134.1 hypothetical protein -
NUS69_RS07040 1221995..1222426 - 432 WP_258083135.1 hypothetical protein -
NUS69_RS07045 1222426..1223268 - 843 WP_258083136.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(19-111)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13472.61 Da        Isoelectric Point: 4.5898

>T253883 WP_258085026.1 NZ_CP102602:c1219012-1218647 [Thermococcus sp. 813A4]
VKVVLQEPGWEEVPTEPHVATLDYALVEGMNAIWKAVRLGELLIEQGKVKVIVLKTLGSSITLFEAHNFFERGLEIGLNE
GITIYDALYIALAEALNAEFLTADEKQYLAAKNYVNAKLLR

Download         Length: 366 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8579.89 Da        Isoelectric Point: 10.3794

>AT253883 WP_258085027.1 NZ_CP102602:c1219247-1219026 [Thermococcus sp. 813A4]
MAIVTVRVPDELKLKMKELNINWSEEIREFIRKRIDEIERKRRIQEALELAKASGSVSRGFAAKSVREDRDSH

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References