Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-AbrB
Location 682293..682909 Replicon chromosome
Accession NZ_CP102602
Organism Thermococcus sp. 813A4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUS69_RS03930 Protein ID WP_258084527.1
Coordinates 682508..682909 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NUS69_RS03925 Protein ID WP_258084526.1
Coordinates 682293..682520 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUS69_RS03905 677544..678545 - 1002 WP_258084523.1 2-hydroxyacid dehydrogenase -
NUS69_RS03910 678671..680119 + 1449 WP_258084924.1 proline--tRNA ligase -
NUS69_RS03915 680166..680552 - 387 WP_258084524.1 pyrolysin -
NUS69_RS03920 680642..682252 + 1611 WP_258084525.1 carbamoyltransferase -
NUS69_RS03925 682293..682520 + 228 WP_258084526.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NUS69_RS03930 682508..682909 + 402 WP_258084527.1 PIN domain-containing protein Toxin
NUS69_RS03935 683056..684225 + 1170 WP_258084925.1 pyridoxal phosphate-dependent aminotransferase -
NUS69_RS03940 684222..684866 - 645 WP_258084528.1 metallophosphoesterase -
NUS69_RS03945 684881..685741 - 861 WP_258084529.1 M48 family metalloprotease -
NUS69_RS03950 685744..686286 - 543 WP_258084530.1 adenylate kinase family protein -
NUS69_RS03955 686426..686641 + 216 WP_055428707.1 hypothetical protein -
NUS69_RS03960 686687..687904 - 1218 WP_258084531.1 methionine adenosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(4-43)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15505.70 Da        Isoelectric Point: 4.7196

>T253882 WP_258084527.1 NZ_CP102602:682508-682909 [Thermococcus sp. 813A4]
MRGVIDTNVLIYDTFEDSEFHGEAERILESLDAWYVPTIVLQEFAWFFRNEGFSADETWEVLRGYLDDPRFRGLNDDSQI
VKKAFEILKVEKLSLSRFNDAMILVHAVEKGVLVTFDSKFRKLAERRGVKVLP

Download         Length: 402 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8795.46 Da        Isoelectric Point: 10.6410

>AT253882 WP_258084526.1 NZ_CP102602:682293-682520 [Thermococcus sp. 813A4]
MGVTKVTRNYQITIPAEIRKALGIKEGELLEVHLEGDRIVLKRLERKRKRLRLRRKLTPKDIEKAIEEGMKECAE

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References