Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 574139..574745 Replicon chromosome
Accession NZ_CP102602
Organism Thermococcus sp. 813A4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUS69_RS03345 Protein ID WP_258084426.1
Coordinates 574139..574537 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NUS69_RS03350 Protein ID WP_258084427.1
Coordinates 574524..574745 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUS69_RS03320 569649..570695 - 1047 WP_258084421.1 Xaa-Pro dipeptidase PepQ -
NUS69_RS03325 570820..571482 + 663 WP_258084422.1 haloacid dehalogenase -
NUS69_RS03330 571533..571799 + 267 WP_258084423.1 50S ribosomal protein L35ae -
NUS69_RS03335 571845..572981 + 1137 WP_258084424.1 tRNA (guanine(10)-N(2))-dimethyltransferase -
NUS69_RS03340 573048..574142 + 1095 WP_258084425.1 VIT1/CCC1 transporter family protein -
NUS69_RS03345 574139..574537 - 399 WP_258084426.1 type II toxin-antitoxin system VapC family toxin Toxin
NUS69_RS03350 574524..574745 - 222 WP_258084427.1 hypothetical protein Antitoxin
NUS69_RS03355 574793..576193 - 1401 WP_258084428.1 MATE family efflux transporter -
NUS69_RS03360 576302..576493 - 192 WP_055428825.1 50S ribosomal protein L37e -
NUS69_RS03365 576519..576749 - 231 WP_055428824.1 LSm family protein -
NUS69_RS03370 576901..579186 + 2286 WP_258084429.1 alpha-amylase family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(4-129)

Antitoxin

Putative antitoxin VapB3-like

(1-73)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14936.34 Da        Isoelectric Point: 4.9888

>T253881 WP_258084426.1 NZ_CP102602:c574537-574139 [Thermococcus sp. 813A4]
VIAIDASVLAKYILLEPGWEQVEELLLKDVISLDYALVEVSNALWKHHVLYGRISREEFERRSRVIDAIPNVVVLENGVE
YLPPARGIALEHKITVYDALYIAQALKYGKLATSDEKQGEIAKKLGIEVFYL

Download         Length: 399 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8706.02 Da        Isoelectric Point: 10.2536

>AT253881 WP_258084427.1 NZ_CP102602:c574745-574524 [Thermococcus sp. 813A4]
MAVISVRVPDELKEKMKKYDINWSEEIRRFIALRISKEEKKRTLERMHELLAGGTPTREGTAKRYVREDRDSN

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References