Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1020470..1020968 Replicon chromosome
Accession NZ_CP102583
Organism Streptococcus pneumoniae strain D39Mega17545

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag MOP79_RS05310 Protein ID WP_001809704.1
Coordinates 1020714..1020968 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag MOP79_RS05305 Protein ID WP_000208080.1
Coordinates 1020470..1020712 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP79_RS05285 1016292..1017467 + 1176 WP_000886145.1 A/G-specific adenine glycosylase -
MOP79_RS05290 1017522..1018226 + 705 WP_000722076.1 response regulator YycF -
MOP79_RS05295 1018219..1019568 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
MOP79_RS05300 1019570..1020379 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
MOP79_RS05305 1020470..1020712 + 243 WP_000208080.1 DUF6290 family protein Antitoxin
MOP79_RS05310 1020714..1020968 + 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOP79_RS05315 1021043..1022914 + 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T253871 WP_001809704.1 NZ_CP102583:1020714-1020968 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT253871 WP_000208080.1 NZ_CP102583:1020470-1020712 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References