Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 873115..873783 Replicon chromosome
Accession NZ_CP102583
Organism Streptococcus pneumoniae strain D39Mega17545

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag MOP79_RS04505 Protein ID WP_001132285.1
Coordinates 873115..873294 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag MOP79_RS04510 Protein ID WP_000961810.1
Coordinates 873331..873783 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOP79_RS04475 868133..868978 + 846 WP_000819520.1 carbohydrate ABC transporter permease -
MOP79_RS04480 868988..870307 + 1320 WP_000608887.1 glycoside hydrolase family 32 protein -
MOP79_RS04490 870854..872125 - 1272 WP_001113205.1 replication-associated recombination protein A -
MOP79_RS04495 872395..872634 + 240 WP_000818079.1 hypothetical protein -
MOP79_RS04500 872799..872978 + 180 WP_001809903.1 hypothetical protein -
MOP79_RS04505 873115..873294 + 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
MOP79_RS04510 873331..873783 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MOP79_RS04515 874074..874544 + 471 WP_000257105.1 DUF3013 family protein -
MOP79_RS04520 874563..875666 + 1104 WP_000719717.1 site-2 protease family protein -
MOP79_RS04525 875632..876060 + 429 WP_000418176.1 NUDIX hydrolase -
MOP79_RS04530 876198..877148 + 951 WP_000451131.1 50S ribosomal protein L11 methyltransferase -
MOP79_RS04535 877150..877893 + 744 WP_001188203.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T253869 WP_001132285.1 NZ_CP102583:873115-873294 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT253869 WP_000961810.1 NZ_CP102583:873331-873783 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References