Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 874288..874945 Replicon chromosome
Accession NZ_CP102552
Organism Klebsiella pneumoniae strain KPH3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NUG48_RS04415 Protein ID WP_002916310.1
Coordinates 874535..874945 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NUG48_RS04410 Protein ID WP_002916312.1
Coordinates 874288..874554 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG48_RS04385 (NUG48_04385) 869444..870877 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NUG48_RS04390 (NUG48_04390) 870996..871724 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NUG48_RS04395 (NUG48_04395) 871774..872085 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
NUG48_RS04400 (NUG48_04400) 872249..872908 + 660 WP_002916317.1 hemolysin III family protein -
NUG48_RS04405 (NUG48_04405) 873059..874042 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
NUG48_RS04410 (NUG48_04410) 874288..874554 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NUG48_RS04415 (NUG48_04415) 874535..874945 + 411 WP_002916310.1 protein YgfX Toxin
NUG48_RS04420 (NUG48_04420) 874952..875473 - 522 WP_002916308.1 flavodoxin FldB -
NUG48_RS04425 (NUG48_04425) 875574..876470 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NUG48_RS04430 (NUG48_04430) 876493..877206 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NUG48_RS04435 (NUG48_04435) 877212..878945 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T253853 WP_002916310.1 NZ_CP102552:874535-874945 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT253853 WP_002916312.1 NZ_CP102552:874288-874554 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References