Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 103185..103828 Replicon plasmid p2
Accession NZ_CP102548
Organism Klebsiella pneumoniae strain KPH1

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag NUG47_RS27530 Protein ID WP_001044768.1
Coordinates 103412..103828 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag NUG47_RS27525 Protein ID WP_001261287.1
Coordinates 103185..103415 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG47_RS27515 (98363) 98363..99496 - 1134 WP_000545983.1 DUF3800 domain-containing protein -
NUG47_RS27520 (99759) 99759..102878 - 3120 WP_001553851.1 hypothetical protein -
NUG47_RS27525 (103185) 103185..103415 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NUG47_RS27530 (103412) 103412..103828 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
NUG47_RS27535 (103990) 103990..106128 - 2139 WP_000350635.1 AAA family ATPase -
NUG47_RS27540 (106593) 106593..107588 + 996 WP_000246636.1 hypothetical protein -
NUG47_RS27545 (107631) 107631..108524 + 894 WP_001553853.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(B) / dfrA12 / aadA2 / qacE / sul1 / blaNDM-1 - 1..125297 125297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T253848 WP_001044768.1 NZ_CP102548:103412-103828 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT253848 WP_001261287.1 NZ_CP102548:103185-103415 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References