Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4421497..4422154 Replicon chromosome
Accession NZ_CP102546
Organism Klebsiella pneumoniae strain KPH1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NUG47_RS21825 Protein ID WP_002916310.1
Coordinates 4421744..4422154 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NUG47_RS21820 Protein ID WP_002916312.1
Coordinates 4421497..4421763 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG47_RS21795 (4416653) 4416653..4418086 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
NUG47_RS21800 (4418205) 4418205..4418933 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
NUG47_RS21805 (4418983) 4418983..4419294 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
NUG47_RS21810 (4419458) 4419458..4420117 + 660 WP_002916317.1 hemolysin III family protein -
NUG47_RS21815 (4420268) 4420268..4421251 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
NUG47_RS21820 (4421497) 4421497..4421763 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NUG47_RS21825 (4421744) 4421744..4422154 + 411 WP_002916310.1 protein YgfX Toxin
NUG47_RS21830 (4422161) 4422161..4422682 - 522 WP_004144730.1 flavodoxin FldB -
NUG47_RS21835 (4422783) 4422783..4423679 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
NUG47_RS21840 (4423702) 4423702..4424415 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NUG47_RS21845 (4424421) 4424421..4426154 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T253841 WP_002916310.1 NZ_CP102546:4421744-4422154 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT253841 WP_002916312.1 NZ_CP102546:4421497-4421763 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References