Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3557243..3557868 Replicon chromosome
Accession NZ_CP102546
Organism Klebsiella pneumoniae strain KPH1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUG47_RS17545 Protein ID WP_040182550.1
Coordinates 3557243..3557626 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag NUG47_RS17550 Protein ID WP_004150355.1
Coordinates 3557626..3557868 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG47_RS17530 (3554609) 3554609..3555511 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
NUG47_RS17535 (3555508) 3555508..3556143 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
NUG47_RS17540 (3556140) 3556140..3557069 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
NUG47_RS17545 (3557243) 3557243..3557626 - 384 WP_040182550.1 type II toxin-antitoxin system VapC family toxin Toxin
NUG47_RS17550 (3557626) 3557626..3557868 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
NUG47_RS17555 (3558073) 3558073..3558990 + 918 WP_023302328.1 alpha/beta hydrolase -
NUG47_RS17560 (3559004) 3559004..3559945 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
NUG47_RS17565 (3559990) 3559990..3560427 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
NUG47_RS17570 (3560424) 3560424..3561284 - 861 WP_004146232.1 virulence factor BrkB family protein -
NUG47_RS17575 (3561278) 3561278..3561877 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14376.67 Da        Isoelectric Point: 9.5352

>T253838 WP_040182550.1 NZ_CP102546:c3557626-3557243 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLKLITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT253838 WP_004150355.1 NZ_CP102546:c3557868-3557626 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References