Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 2993993..2994803 Replicon chromosome
Accession NZ_CP102546
Organism Klebsiella pneumoniae strain KPH1

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag NUG47_RS14910 Protein ID WP_014908042.1
Coordinates 2993993..2994526 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag NUG47_RS14915 Protein ID WP_023343051.1
Coordinates 2994537..2994803 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG47_RS14905 (2992824) 2992824..2993945 + 1122 WP_012737335.1 cupin domain-containing protein -
NUG47_RS14910 (2993993) 2993993..2994526 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
NUG47_RS14915 (2994537) 2994537..2994803 - 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
NUG47_RS14920 (2994906) 2994906..2996339 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
NUG47_RS14925 (2996329) 2996329..2997012 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
NUG47_RS14930 (2997185) 2997185..2998570 + 1386 WP_040182471.1 efflux transporter outer membrane subunit -
NUG47_RS14935 (2998588) 2998588..2998932 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T253835 WP_014908042.1 NZ_CP102546:c2994526-2993993 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT253835 WP_023343051.1 NZ_CP102546:c2994803-2994537 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References