Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 983284..984872 Replicon chromosome
Accession NZ_CP102546
Organism Klebsiella pneumoniae strain KPH1

Toxin (Protein)


Gene name hipA Uniprot ID A0A486S9S0
Locus tag NUG47_RS05030 Protein ID WP_023301940.1
Coordinates 983284..984606 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NUG47_RS05035 Protein ID WP_002904790.1
Coordinates 984606..984872 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG47_RS05015 (978340) 978340..980841 + 2502 WP_040182042.1 fimbria/pilus outer membrane usher protein -
NUG47_RS05020 (980829) 980829..981833 + 1005 WP_009308876.1 fimbrial protein -
NUG47_RS05025 (981975) 981975..983267 + 1293 WP_016946381.1 glycoside hydrolase family 10 protein -
NUG47_RS05030 (983284) 983284..984606 - 1323 WP_023301940.1 type II toxin-antitoxin system HipA family toxin Toxin
NUG47_RS05035 (984606) 984606..984872 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NUG47_RS05040 (985138) 985138..985464 - 327 WP_004143476.1 hydroxyisourate hydrolase -
NUG47_RS05045 (985461) 985461..985961 - 501 WP_040182039.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NUG47_RS05050 (985939) 985939..987318 - 1380 WP_004176204.1 nucleobase:cation symporter-2 family protein -
NUG47_RS05055 (987664) 987664..988818 + 1155 WP_040182036.1 FAD-dependent urate hydroxylase HpxO -
NUG47_RS05060 (988799) 988799..989722 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49185.49 Da        Isoelectric Point: 7.5358

>T253833 WP_023301940.1 NZ_CP102546:c984606-983284 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT253833 WP_002904790.1 NZ_CP102546:c984872-984606 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486S9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References