253826

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2438899..2439464 Replicon chromosome
Accession NZ_CP102542
Organism Lacticaseibacillus rhamnosus strain GR-1

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag NUU07_RS11205 Protein ID WP_005692155.1
Coordinates 2438899..2439246 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NUU07_RS11210 Protein ID WP_020752297.1
Coordinates 2439246..2439464 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU07_RS11185 (NUU07_11180) 2434516..2435757 - 1242 WP_005692160.1 acyltransferase -
NUU07_RS11190 (NUU07_11185) 2435754..2436455 - 702 WP_064522467.1 ATP-binding cassette domain-containing protein -
NUU07_RS11195 (NUU07_11190) 2436448..2437266 - 819 WP_014571588.1 ABC transporter permease subunit -
NUU07_RS11200 (NUU07_11195) 2437507..2438175 - 669 WP_005692157.1 phenylalanine--tRNA ligase beta subunit-related protein -
NUU07_RS11205 (NUU07_11200) 2438899..2439246 - 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NUU07_RS11210 (NUU07_11205) 2439246..2439464 - 219 WP_020752297.1 hypothetical protein Antitoxin
NUU07_RS11215 (NUU07_11210) 2439558..2441393 - 1836 WP_015764721.1 ABC transporter ATP-binding protein -
NUU07_RS11220 (NUU07_11215) 2441380..2443170 - 1791 WP_005692150.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T253826 WP_005692155.1 NZ_CP102542:c2439246-2438899 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8117.33 Da        Isoelectric Point: 5.7995

>AT253826 WP_020752297.1 NZ_CP102542:c2439464-2439246 [Lacticaseibacillus rhamnosus]
MMDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75

Antitoxin

Source ID Structure

References