Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1652546..1653101 Replicon chromosome
Accession NZ_CP102541
Organism Bifidobacterium longum subsp. infantis strain BB-02

Toxin (Protein)


Gene name mazF Uniprot ID S2ZXD7
Locus tag NUU11_RS07735 Protein ID WP_003829109.1
Coordinates 1652778..1653101 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NUU11_RS07730 Protein ID WP_212105461.1
Coordinates 1652546..1652791 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU11_RS07710 (NUU11_07710) 1648373..1649035 + 663 WP_019728044.1 TetR/AcrR family transcriptional regulator -
NUU11_RS07715 (NUU11_07715) 1649192..1650463 + 1272 WP_025341702.1 MFS transporter -
NUU11_RS07720 (NUU11_07720) 1650647..1650796 - 150 WP_234933099.1 XRE family transcriptional regulator -
NUU11_RS07725 (NUU11_07725) 1651116..1652372 - 1257 WP_212105458.1 HipA domain-containing protein -
NUU11_RS07730 (NUU11_07730) 1652546..1652791 + 246 WP_212105461.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUU11_RS07735 (NUU11_07735) 1652778..1653101 + 324 WP_003829109.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NUU11_RS07740 (NUU11_07740) 1653318..1653932 - 615 WP_195338371.1 cupin domain-containing protein -
NUU11_RS07745 (NUU11_07745) 1654027..1654896 - 870 WP_212105464.1 class I SAM-dependent methyltransferase -
NUU11_RS07750 (NUU11_07750) 1655134..1655499 + 366 WP_032743659.1 YccF domain-containing protein -
NUU11_RS07755 (NUU11_07755) 1656042..1657307 + 1266 WP_212105467.1 Fic family protein -
NUU11_RS07760 (NUU11_07760) 1657777..1658075 + 299 Protein_1509 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11859.67 Da        Isoelectric Point: 5.0771

>T253823 WP_003829109.1 NZ_CP102541:1652778-1653101 [Bifidobacterium longum subsp. infantis]
MKRGEIWTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9351.49 Da        Isoelectric Point: 4.5881

>AT253823 WP_212105461.1 NZ_CP102541:1652546-1652791 [Bifidobacterium longum subsp. infantis]
MSMQIATRVDDEQAALFKETTRQLGITPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A087B6Q7

Antitoxin

Source ID Structure

References