Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1594256..1594895 Replicon chromosome
Accession NZ_CP102541
Organism Bifidobacterium longum subsp. infantis strain BB-02

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag NUU11_RS07450 Protein ID WP_212105396.1
Coordinates 1594539..1594895 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NUU11_RS07445 Protein ID WP_003829235.1
Coordinates 1594256..1594552 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU11_RS07420 (NUU11_07420) 1589647..1592325 - 2679 WP_212105390.1 alanine--tRNA ligase -
NUU11_RS07425 (NUU11_07425) 1592454..1592690 - 237 WP_029679572.1 hypothetical protein -
NUU11_RS07430 (NUU11_07430) 1592690..1593088 - 399 WP_012577919.1 DUF948 domain-containing protein -
NUU11_RS07435 (NUU11_07435) 1593171..1593845 - 675 WP_212105393.1 histidine phosphatase family protein -
NUU11_RS07440 (NUU11_07440) 1593921..1594109 + 189 WP_234933089.1 hypothetical protein -
NUU11_RS07445 (NUU11_07445) 1594256..1594552 + 297 WP_003829235.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUU11_RS07450 (NUU11_07450) 1594539..1594895 + 357 WP_212105396.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NUU11_RS07455 (NUU11_07455) 1595353..1595688 - 336 WP_234933091.1 transglutaminase family protein -
NUU11_RS07460 (NUU11_07460) 1595793..1596026 - 234 WP_248315138.1 hypothetical protein -
NUU11_RS07465 (NUU11_07465) 1596043..1596432 + 390 WP_234933093.1 cytidine deaminase -
NUU11_RS07470 (NUU11_07470) 1596570..1597352 + 783 WP_212105399.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
NUU11_RS07475 (NUU11_07475) 1597690..1598316 - 627 WP_007052130.1 30S ribosomal protein S4 -
NUU11_RS07480 (NUU11_07480) 1598515..1599507 - 993 WP_212105402.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-111)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(12-54)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13315.26 Da        Isoelectric Point: 7.9984

>T253822 WP_212105396.1 NZ_CP102541:1594539-1594895 [Bifidobacterium longum subsp. infantis]
MMKTDPRQFEIWWVPFAFPDKPGKAKNHPSVILQWDDGTRIALMTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSNLFLDDGPTGRLSAYDAGRVAWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10997.50 Da        Isoelectric Point: 4.2896

>AT253822 WP_003829235.1 NZ_CP102541:1594256-1594552 [Bifidobacterium longum subsp. infantis]
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References